Phenotypes Associated with This Genotype

Genotype
MGI:6423510

• Allelic Composition: Mir140^em1Tkob/Mir140^em1Tkob
• Genetic Background: C57BL/6-Mir140^em1Tkob

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

short nasal bone ( J:286036 )

short snout ( J:286036 )

• shorter nose

decreased body size ( J:286036 )

• mice are smaller at P28

skeleton

short nasal bone ( J:286036 )

platyspondylia ( J:286036 )

• mice show mildly flat vertebral bodies

small vertebral body ( J:286036 )

abnormal cartilage development ( J:286036 )

• mice show delayed cartilage maturation of the larynx, trachea, and anterior ribs

abnormal epiphyseal plate morphology ( J:286036 )

• basal skull growth plate is wider due to increased length of all layers of chondrocytes

abnormal long bone epiphyseal plate morphology ( J:286036 )

• proximal tibial growth plates show an expansion of the resting zone

decreased bone mineralization ( J:286036 )

• severely decreased epiphyseal mineralization

• however, the proliferation rate of tibial growth plate chondrocytes is not different and apoptosis levels in the growth plate are normal

delayed bone ossification ( J:286036 )

• mice show delayed secondary ossification of tubular and carpal bones

craniofacial

short nasal bone ( J:286036 )

short snout ( J:286036 )

• shorter nose

respiratory system

short nasal bone ( J:286036 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
osteochondrodysplasia		DOID:2256		J:286036