Phenotypes Associated with This Genotype

Genotype
MGI:6423598

• Allelic Composition: Lmna^tm1.1Bliu/Lmna^tm1.1Bliu
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:287256 )

• shorter median life span of 21 weeks

growth/size/body

weight loss ( J:287256 )

• body weight loss from 8 weeks of age

postnatal growth retardation ( J:287256 )

cardiovascular system

increased aorta wall thickness ( J:287256 )

• intima-media thickening

abnormal vasodilation ( J:287256 )

• acetylcholine-induced thoracic aorta relaxation is compromised

muscle

abnormal vasodilation ( J:287256 )

• acetylcholine-induced thoracic aorta relaxation is compromised

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
progeria		DOID:3911	OMIM:176670	J:287256