Analysis Tools
mortality/aging
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• 10.8% of males die during postnatal growth
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growth/size/body
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• reduced growth in some males after birth
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behavior/neurological
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• mice show hyperactive behaviors in home cages such as continuous jumping or fighting with littermates
• mice jump more frequently when kept alone in home cages or novel cages without cage lids
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• increase in digging behavior in novel cages
• mice bury more marbles than wild-type mice, indicating compulsive digging in a novel environment
• however, mice show a non-significant increase in repetitive grooming
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• mice show decreased nesting score in the nesting building assay
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• in the 3-chamber social interaction test, mice explore the novel social partner less frequently than wild-type mice
• mice show reduced social interaction with a stimulus mouse during a free dyadic encounter, with a few mice running away from the novel mouse
• however, mice show normal responses to both social and non-social cues indicting normal olfactory function
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• in the 3-chamber social interaction test, mice do not show a preference to explore stranger mouse 2 compared with stranger 1, indicating impaired social novelty recognition
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• P8 pups emit shorter durations of isolation-induced ultrasonic vocalizations
• adult males emit shorter durations of ultrasonic vocalizations when allowed to interact with a novel female mouse
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• young mice exhibit spontaneous seizures, with several mice showing lethal seizures
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nervous system
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• young mice exhibit spontaneous seizures, with several mice showing lethal seizures
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• hippocampal neurons show altered membrane properties, with right hippocampus neurons having higher membrane resistance, smaller capacitance and lower after-hyperpolarization than wild-type neurons while the left hippocampal neurons showing no difference in membrane properties but a lower spike frequency
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• right hippocampal CA1 pyramidal neurons exhibit smaller after-hyperpolarization
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• pyramidal neurons show a reduced frequency of mEPSCs in the left hippocampus and increased frequency of mEPSCs in the right hippocampus
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| autism spectrum disorder | DOID:0060041 | J:270945 | ||
