neoplasm
• mice typically have multiple tumor bearing organs
• tumors are present in 10 of 18 mice at 18-26 months of age compared to 5 of 19 wild-type controls
• tumors are most commonly seen in the spleen, mesenteric lymph nodes, liver, and intestines
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• tumors in the lower gastrointestinal tract often lead to destruction of the mucosal surface
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• some mice have histiocyte-associated lymphoma or B cell lymphoma co-occurring with histiocytic sarcoma
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• tumor cell morphology is frequently consistent with malignant histiocytes, although in some mice tumors have a plasma cell appearance
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hematopoietic system
• frequently enlarged due to proliferation of transformed cells
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immune system
• frequently enlarged due to proliferation of transformed cells
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• frequently enlarged due to proliferation of transformed cells
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liver/biliary system
digestive/alimentary system
• tumors in the lower gastrointestinal tract often lead to destruction of the mucosal surface
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growth/size/body
• frequently enlarged due to proliferation of transformed cells
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
malignant histiocytic disease | DOID:2570 | J:282928 |