Phenotypes Associated with This Genotype

Genotype
MGI:6437930

• Allelic Composition: Shank3^tm2Cmpl/Shank3^tm2Cmpl
• Genetic Background: B6.129S6-Shank3^tm2Cmpl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired spatial learning ( J:289874 )

• mice exhibit increased latency to reach the hidden platform in the Morris water maze

• mice show an increase in distance traveled before reaching the hidden platform during training on the Morris water maze

• mice spend more time in the periphery or thigmotaxis zone of the Morris water maze

abnormal spatial reference memory ( J:289874 )

• mice show no preference for the target quadrant during the probe test for spatial memory 24 hours following the final training session

decreased anxiety-related response ( J:289874 )

• mice show a decrease in the number of marbles buried in the marble-burying task

• however, mice spend similar time in the central, anxiogenic region of the open field as wild-type mice, show a similar latency to enter the light chamber in the dark/light test, and spend similar time in the light and dark chambers, indicating normal anxiety-related responses in these tests, and exhibit normal acoustic startle response and prepulse inhibition

increased grooming behavior ( J:289874 )

• mice show increased time spend grooming

impaired coordination ( J:289874 )

♀ • females show a decreased latency to fall from the rotarod

decreased vertical activity ( J:289874 )

♀ • females show less rearing while males only show a trend toward less rearing

abnormal social investigation ( J:289874 )

• mice show a decrease in approach of a novel, caged social target in the caged conspecific test

• in the genotype and sex-matched social interaction test, mice show a reduction in social interaction time and a decrease in number of social bouts

abnormal response to social novelty ( J:289874 )

• in the third trial of the 3-chamber test of sociability, mice do not show a preference for the social novelty

abnormal social recognition ( J:289874 )

• mice show deficits in social recognition in the social interaction with juvenile test of social memory

nervous system

impaired synaptic plasticity ( J:289874 )

• mice exhibit impaired hippocampal long-term plasticity

• however, mice show no differences from wild-type mice in basal synaptic transmission and short-term plasticity at hippocampal synapses

abnormal synaptic transmission ( J:289874 )

• mice exhibit altered striatal glutamatergic synaptic transmission as indicated by a decreased NMDAR/AMPAR ratio in dorsal striatum

reduced long-term potentiation ( J:289874 )

• mice exhibit decreased hippocampal long-term potentiation

• however, mGluR-dependent long-term depression is normal

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:289874