Phenotypes Associated with This Genotype

Genotype
MGI:6441077

• Allelic Composition: Hdac4^em1Hcu/Hdac4⁺
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased susceptibility to weight gain ( J:280111 )

♀ • females, but not males, gain more weight on a high-fat diet when group housed

♀ • however, on a regular chow, no difference in body weight is seen in either single or grouped mice

behavior/neurological

abnormal operant conditioning behavior ( J:280111 )

♀ • in an operant-responding task to acquire a high fat diet pellet, individually-housed females exhibit fewer nose pokes and earn fewer rewards than wild-type mice, indicating reduced preference for high-fat diet

♀ • however, buried food test shows no impairment of olfaction

increased food intake ( J:280111 )

♀ • when group-housed mice are individually housed temporarily, an increase in consumption of high fat diet overnight is seen

abnormal food preference ( J:280111 )

♀ • in an operant-responding task to acquire a high fat diet pellet, individually-housed females exhibit fewer nose pokes and earn fewer rewards than wild-type mice, indicating reduced preference for high-fat diet

increased coping response ( J:280111 )

♀ • group-housed females show reduced immobility in the forced swim test compared to individually-housed mutant females

increased anxiety-related response ( J:280111 )

♀ • group-housed female mice show reduced time exploring the light side of the light/dark box than individually-housed mutant females

♀ • however, mice show no differences in the three-chamber social interaction, Barnes maze probe trial or social dominance tasks

increased grooming behavior ( J:280111 )

♀ • females, but not males, exhibit increased grooming

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
eating disorder		DOID:8670		J:280111