Phenotypes Associated with This Genotype

Genotype
MGI:6444681

• Allelic Composition: Ikbkb^em1Macc/Ikbkb⁺
• Genetic Background: involves: C57BL/6NCrl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased B cell number ( J:290616 )

decreased memory B cell number ( J:290616 )

abnormal effector T cell number ( J:290616 )

• increase in the number of effector T cells

increased regulatory T cell number ( J:290616 )

• small increase in circulating T reg cells and within the thymus

decreased T cell number ( J:290616 )

• T cells are reduced as a proportion of splenocytes

• reduction in absolute number of T cells within spleens

decreased CD4-positive, alpha-beta T cell number ( J:290616 )

• reduction in absolute numbers of CD4+ T cells

decreased CD8-positive, alpha-beta T cell number ( J:290616 )

• reduction in absolute numbers of CD8+ T cells

abnormal T cell activation ( J:290616 )

• increase in T cell activation

immune system

decreased B cell number ( J:290616 )

decreased memory B cell number ( J:290616 )

abnormal effector T cell number ( J:290616 )

• increase in the number of effector T cells

increased regulatory T cell number ( J:290616 )

• small increase in circulating T reg cells and within the thymus

decreased T cell number ( J:290616 )

• T cells are reduced as a proportion of splenocytes

• reduction in absolute number of T cells within spleens

decreased CD4-positive, alpha-beta T cell number ( J:290616 )

• reduction in absolute numbers of CD4+ T cells

decreased CD8-positive, alpha-beta T cell number ( J:290616 )

• reduction in absolute numbers of CD8+ T cells

abnormal T cell activation ( J:290616 )

• increase in T cell activation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
immunodeficiency 15A		DOID:0111960	OMIM:618204	J:290616