Phenotypes Associated with This Genotype

Genotype
MGI:6449734

hm3

• Allelic Composition: Tiparp^{Gt(ROSA)79Sor}/Tiparp^{Gt(ROSA)79Sor}
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased fasting circulating glucose level ( J:250417 )

• dioxin-treated mice show reduced fasting serum glucose levels from day 1 to 3

increased circulating alanine transaminase level ( J:250417 )

• dioxin-treated mice show increased serum alanine aminotransferase activity

increased susceptibility to xenobiotic induced morbidity/mortality ( J:250417 )

• mice exhibit increased sensitivity to dioxin-induced lethality, with mice becoming moribund between 3 and 5 days

increased physiological sensitivity to xenobiotic ( J:250417 )

• mice exhibit increased sensitivity to dioxin-induced toxicity, showing decreased body weight, reduced fasting serum glucose levels, induction of thymic involution, hepatomegaly, liver degeneration, and increased hepatosteatosis

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:250417 )

• mice exhibit increased sensitivity to dioxin-induced lethality, with mice becoming moribund between 3 and 5 days

endocrine/exocrine glands

abnormal thymus involution ( J:250417 )

• dioxin-treatment induces thymic involution

growth/size/body

increased susceptibility to weight loss ( J:250417 )

• dioxin-treated mice show reduced body weight on day 3 due to decreased food intake on days 1 and 2

enlarged liver ( J:250417 )

• dioxin-treated mice show hepatomegaly

hematopoietic system

abnormal thymus involution ( J:250417 )

• dioxin-treatment induces thymic involution

immune system

abnormal thymus involution ( J:250417 )

• dioxin-treatment induces thymic involution

liver/biliary system

enlarged liver ( J:250417 )

• dioxin-treated mice show hepatomegaly

hepatic steatosis ( J:250417 )

• mice exhibit increased dioxin-induced hepatosteatosis, showing increases in intrahepatic triglycerides, cholesterol and free fatty acids levels

• expression analysis suggest that increased sensitivity to dioxin-induced hepatosteatosis is due to increased uptake of circulating lipids rather than increased hepatic lipogenesis

liver degeneration ( J:250417 )

• dioxin-treated mice show increased degenerative changes in the liver, including focal inflammatory infiltration and increased cytoplasmic clearing of periportal hepatocytes on day 1 and microvesicular steatosis with regions of focal vacuolation on day 3

• dioxin-treated mice exhibit increased hepatic expression of Il1-beta and Cxcl2