Phenotypes Associated with This Genotype

Genotype
MGI:6451096

• Allelic Composition: Cfap65^em1Fzh/Cfap65^em1Fzh
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal sperm axoneme morphology ( J:292578 )

♂ • the axoneme is completely disorganized in testicular spermatozoa

♂ • sperm flagella lack the central pair of microtubules and the 9 peripheral microtubule doublets are scattered irregularly

absent sperm axonemal central pair ( J:292578 )

♂ • sperm flagella lack the central pair of microtubules

absent sperm flagellum ( J:292578 )

♂ • 33.6% of mice exhibit absent spermatozoa flagella

coiled sperm flagellum ( J:292578 )

♂ • 14.3% of mice exhibit coiled sperm flagellum

short sperm flagellum ( J:292578 )

♂ • 48.4% of mice exhibit short spermatozoa flagella

increased male germ cell apoptosis ( J:292578 )

♂ • many aberrant spermatozoa undergo apoptosis

asthenozoospermia ( J:292578 )

• complete loss of progressive sperm motility and sperm motility

male infertility ( J:292578 )

♂ • males are infertile

♂ • however, females are fertile

cellular

abnormal sperm axoneme morphology ( J:292578 )

♂ • the axoneme is completely disorganized in testicular spermatozoa

♂ • sperm flagella lack the central pair of microtubules and the 9 peripheral microtubule doublets are scattered irregularly

absent sperm axonemal central pair ( J:292578 )

♂ • sperm flagella lack the central pair of microtubules

absent sperm flagellum ( J:292578 )

♂ • 33.6% of mice exhibit absent spermatozoa flagella

coiled sperm flagellum ( J:292578 )

♂ • 14.3% of mice exhibit coiled sperm flagellum

short sperm flagellum ( J:292578 )

♂ • 48.4% of mice exhibit short spermatozoa flagella

increased male germ cell apoptosis ( J:292578 )

♂ • many aberrant spermatozoa undergo apoptosis

asthenozoospermia ( J:292578 )

• complete loss of progressive sperm motility and sperm motility

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
spermatogenic failure 40		DOID:0111918	OMIM:618664	J:292578