Phenotypes Associated with This Genotype

Genotype
MGI:6460345

• Allelic Composition: Akt1^tm1Mjl/Akt1⁺; Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal blood vessel morphology ( J:293971 )

• vascular malformations are seen in lymph nodes, spleen, and/or other locations in mice from pregnant females treated with tamoxifen at E5.5

• visible vascular malformations appear as dark, blood-filled, often multi-lobulated cystic masses

• vascular malformations are characterized as venous-capillary mixed-type malformations with ectatic channels and often containing a lymphatic component and no atypia

• numerous, variably-sized, thin-walled ectatic vessels, often separated by increased stroma are seen in these lesion

endocrine/exocrine glands

biliary cyst ( J:293971 )

• biliary cysts are the most frequent type of cyst seen in mice from pregnant females treated with tamoxifen at E5.5

dilated bile duct ( J:293971 )

• biliary ductule ectasia is seen in some mice treated with tamoxifen at E5.5

abnormal mammary gland duct morphology ( J:293971 )

• mammary changes in mice treated with tamoxifen at E5.5 include ductal ectasia

mammary gland alveolar hyperplasia ( J:293971 )

• seen in some mice treated with tamoxifen at E5.5

abnormal mammary gland stroma morphology ( J:293971 )

• mammary changes in mice treated with tamoxifen at E5.5 include expansion of the supporting stroma

mammary gland hyperplasia ( J:293971 )

• overgrowth of breast tissue is seen in mice from pregnant females treated with tamoxifen at E5.5

integument

abnormal mammary gland duct morphology ( J:293971 )

• mammary changes in mice treated with tamoxifen at E5.5 include ductal ectasia

mammary gland alveolar hyperplasia ( J:293971 )

• seen in some mice treated with tamoxifen at E5.5

abnormal mammary gland stroma morphology ( J:293971 )

• mammary changes in mice treated with tamoxifen at E5.5 include expansion of the supporting stroma

mammary gland hyperplasia ( J:293971 )

• overgrowth of breast tissue is seen in mice from pregnant females treated with tamoxifen at E5.5

liver/biliary system

biliary cyst ( J:293971 )

• biliary cysts are the most frequent type of cyst seen in mice from pregnant females treated with tamoxifen at E5.5

dilated bile duct ( J:293971 )

• biliary ductule ectasia is seen in some mice treated with tamoxifen at E5.5

growth/size/body

biliary cyst ( J:293971 )

• biliary cysts are the most frequent type of cyst seen in mice from pregnant females treated with tamoxifen at E5.5

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Proteus syndrome		DOID:13482	OMIM:176920	J:293971