Phenotypes Associated with This Genotype

Genotype
MGI:6467272

• Allelic Composition: Foxp3^{tm4(YFP/icre)Ayr}/Foxp3^{tm4(YFP/icre)Ayr}; Ikzf4^tm1Djr/Ikzf4^tm1Djr
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

small intestinal inflammation ( J:294549 )

• increased lymphocyte infiltration and neutrophils in lamina propria at age 3 months

enlarged spleen ( J:294549 )

• slight splenomegaly at age 2 months, marked splenomegaly at age 3 months

increased germinal center B cell number ( J:294549 )

• increased percentage in immunized and unimmunized mice at age 3 months

decreased regulatory T cell number ( J:294549 )

• reduced percentage of regulatory follicular T cells in immunized and unimmunized mice at age 3 months

increased T cell number ( J:294549 )

• increased absolute total CD4+, CD8+ and regulatory T cell numbers at age 3 months

• elevated percentage of regulatory T cells at age 3 months

• elevated percentage of CD44hi-CD62Llo CD4+, CD8+ and regulatory T cells at age 3 months

• increased percentage of follicular T cells in unimmunized mice at age 3 months

increased T follicular helper cell number ( J:294549 )

• increased percentage in unimmunized mice at age 3 months

increased spleen B cell follicle number ( J:294549 )

• increased number in immunized mice at age 3 months

increased spleen germinal center number ( J:294549 )

• increased number in immunized mice at age 3 months

increased immunoglobulin level ( J:294549 )

• increased serum levels of all immunoglobulin isotypes and anti-nuclear antibodies (ANA) at age 3 months

enlarged lymph nodes ( J:294549 )

• slight lymphadenopathy at age 2 months, marked lymphadenopathy at age 3 months

increased susceptibility to experimental autoimmune encephalomyelitis ( J:294549 )

• at age 3 months

chronic inflammation ( J:294549 )

• increased lymphocyte infiltration in small intestine, lungs, liver, salivary glands and kidneys at age 3 months

granulomatous inflammation ( J:294549 )

• hepatic microgranulomas at age 3 months

glomerulonephritis ( J:294549 )

• at age 3 months

hematopoietic system

enlarged spleen ( J:294549 )

• slight splenomegaly at age 2 months, marked splenomegaly at age 3 months

increased germinal center B cell number ( J:294549 )

• increased percentage in immunized and unimmunized mice at age 3 months

decreased regulatory T cell number ( J:294549 )

• reduced percentage of regulatory follicular T cells in immunized and unimmunized mice at age 3 months

increased T cell number ( J:294549 )

• increased absolute total CD4+, CD8+ and regulatory T cell numbers at age 3 months

• elevated percentage of regulatory T cells at age 3 months

• elevated percentage of CD44hi-CD62Llo CD4+, CD8+ and regulatory T cells at age 3 months

• increased percentage of follicular T cells in unimmunized mice at age 3 months

increased T follicular helper cell number ( J:294549 )

• increased percentage in unimmunized mice at age 3 months

increased spleen B cell follicle number ( J:294549 )

• increased number in immunized mice at age 3 months

increased spleen germinal center number ( J:294549 )

• increased number in immunized mice at age 3 months

increased immunoglobulin level ( J:294549 )

• increased serum levels of all immunoglobulin isotypes and anti-nuclear antibodies (ANA) at age 3 months

growth/size/body

enlarged spleen ( J:294549 )

• slight splenomegaly at age 2 months, marked splenomegaly at age 3 months

digestive/alimentary system

abnormal small intestine morphology ( J:294549 )

• hyperplastic epithelium at age 3 months

decreased small intestinal microvillus size ( J:294549 )

• blunted at age 3 months

small intestinal inflammation ( J:294549 )

• increased lymphocyte infiltration and neutrophils in lamina propria at age 3 months

renal/urinary system

glomerulonephritis ( J:294549 )

• at age 3 months

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
encephalomyelitis		DOID:640		J:294549