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Phenotypes Associated with This Genotype
Genotype
MGI:6472960
cx4
Allelic
Composition		 Agxttm1Ull/Agxttm1Ull
Prodh2em1Jkni/Prodh2em1Jkni
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agxttm1Ull mutation (0 available); any Agxt mutation (16 available)
Prodh2em1Jkni mutation (0 available); any Prodh2 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal urine homeostasis ( J:283585 )
• mice show lowered urinary glycolate levels compared to single Agxt homozygotes
hyperoxaluria ( J:283585 )
• mice show increased urinary oxalate excretion compared to wild-type mice but reduced excretion compared to single Agxt homozygotes

renal/urinary system
abnormal urine homeostasis ( J:283585 )
• mice show lowered urinary glycolate levels compared to single Agxt homozygotes
hyperoxaluria ( J:283585 )
• mice show increased urinary oxalate excretion compared to wild-type mice but reduced excretion compared to single Agxt homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory