Phenotypes Associated with This Genotype

Genotype
MGI:6473965

• Allelic Composition: Vwf^tm1.1Vhf/Vwf^tm1.1Vhf
• Genetic Background: involves: C57BL/6J * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal platelet physiology ( J:295694 )

• blood shows a decrease in platelet adhesion to type IV collagen under flow

• however, mice exhibit normal platelet aggregation induced by type I or type IV collagen under static conditions

homeostasis/metabolism

abnormal blood coagulation ( J:295694 )

• occlusion time in the ferric chloride-induced injury model is slower than in wild-type mice

abnormal platelet physiology ( J:295694 )

• blood shows a decrease in platelet adhesion to type IV collagen under flow

• however, mice exhibit normal platelet aggregation induced by type I or type IV collagen under static conditions

decreased susceptibility to induced thrombosis ( J:295694 )

• thrombosis induced by ferric chloride-induced injury is decreased

increased bleeding time ( J:295694 )

• homozygous mice bleed longer than heterozygous or wild-type mice and show increased blood loss in the tail clip bleeding model

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
von Willebrand's disease		DOID:12531		J:295694