mortality/aging
• sudden unexpected death is seen in 30% of mice during a 36-week follow-up
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cardiovascular system
• hearts show enlarged cardiac chambers at 4 weeks of age which is exacerbated at 12 weeks of age
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• hearts show thinning of the ventricular wall at 4 weeks of age which is exacerbated at 12 weeks of age
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• cardiac fibrosis is seen at 4 weeks of age and fibrotic left ventricle changes are exacerbated at 12 weeks of age
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• ultrasound echocardiography shows a far lower fractional shortening at 12-16 weeks of age than in wild-type mice
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• ultrasound echocardiography shows a far lower fractional shortening, larger left ventricular end-diastolic diameter, and thinner end-diastolic left ventricular posterior wall thickness at 12-16 weeks of age
• mice show lower percent fractional shortening, larger left ventricle end-diastolic diameter, and lower end-diastolic left ventricular poster wall thickness at 4 weeks of age, when atrial fibrillation is not observed
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• 2 of 3 mice show spontaneous, sustained, and self-terminating ventricular tachycardia and ventricular fibrillation
• during ventricular tachycardia episode, mice suffer syncope
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• mice start developing atrial fibrillation at approximately 4 weeks and atrial fibrillation is present in all mice at 10 weeks of age
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• 2 of 3 mice show spontaneous, sustained, and self-terminating ventricular tachycardia and ventricular fibrillation
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• prolonged PR interval in 4-week old mice
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• prolonged P wave duration in 4-week old mice
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• prolonged QRS duration in 4-week old mice
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• prolonged heart rate-corrected QT interval in 4-week old mice
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• smaller R amplitude in 4-week old mice
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growth/size/body
• hearts show enlarged cardiac chambers at 4 weeks of age which is exacerbated at 12 weeks of age
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muscle
• ultrasound echocardiography shows a far lower fractional shortening at 12-16 weeks of age than in wild-type mice
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
atrial fibrillation | DOID:0060224 | J:297234 | ||
dilated cardiomyopathy 1DD | DOID:0110447 |
OMIM:613172 |
J:297234 |