Phenotypes Associated with This Genotype

Genotype
MGI:6477557

hm1

• Allelic Composition: Hhipl1^{tm1a(KOMP)Wtsi}/Hhipl1^{tm1a(KOMP)Wtsi}
• Genetic Background: B6J.B6N-Hhipl1^{tm1a(KOMP)Wtsi}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:280707 )

N • mice are born at normal Mendelian frequencies and show no perinatal or postnatal lethality

growth/size/body

growth/size/body region phenotype ( J:280707 )

N • mice show no signs of dysmorphology or differences in body weight relative to wild-type controls

cardiovascular system

abnormal vascular smooth muscle physiology ( J:280707 )

• in vitro, aortic smooth muscle cells (AoSMCs) display significantly reduced migration relative to wild-type AoSMCs

decreased vascular smooth muscle cell proliferation ( J:280707 )

• in vitro, AoSMCs show significantly reduced proliferation relative to wild-type AoSMCs

• however, no differences in apoptosis are observed

muscle

abnormal vascular smooth muscle physiology ( J:280707 )

• in vitro, aortic smooth muscle cells (AoSMCs) display significantly reduced migration relative to wild-type AoSMCs

decreased vascular smooth muscle cell proliferation ( J:280707 )

• in vitro, AoSMCs show significantly reduced proliferation relative to wild-type AoSMCs

• however, no differences in apoptosis are observed

cellular

decreased vascular smooth muscle cell proliferation ( J:280707 )

• in vitro, AoSMCs show significantly reduced proliferation relative to wild-type AoSMCs

• however, no differences in apoptosis are observed

decreased cell migration ( J:280707 )

• in a scratch wound assay, the migration rate of AoSMCs is significantly lower than that of wild-type AoSMCs