Analysis Tools
cardiovascular system
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• after 12 weeks on a high-fat Western diet, male double homozygotes show a 57% reduction in % aortic lesion area by en face analysis and a 37% reduction in mean plaque area in aortic roots with smaller lipid cores relative to single Ldlrtm1Her homozygotes
• under a Western diet, aortic root lesions of double homozygotes show a 46% reduction in anti-alpha smooth muscle actin (SMA)-positive staining indicating reduced smooth muscle cell content but no differences in lipid, macrophage or collagen content within plaques
• no differences in body weight, plasma lipid levels or blood pressure are observed relative to single Ldlrtm1Her homozygotes
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