Analysis Tools
cardiovascular system
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• after 12 weeks on a high-fat Western diet, male double homozygotes show a 53% reduction in % aortic lesion area by en face analysis and a 33% reduction in mean plaque area in aortic roots relative to single Apoetm1Unc homozygotes
• under a Western diet, aortic root lesions of double homozygotes show a 47% reduction in SMA-positive staining indicating reduced smooth muscle cell content as well as a reduction in lipid content but no differences in macrophage or collagen content within plaques
• no differences in body weight, plasma lipid levels or blood pressure are observed relative to single Apoetm1Unc homozygotes
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