Phenotypes Associated with This Genotype

Genotype
MGI:6478907

cx45

• Allelic Composition: Dmd^mdx/Dmd^mdx; Snhg15^tm1Nju/Snhg15^tm1Nju
• Genetic Background: involves: C57BL/6J * C57BL/10ScSn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

growth/size/body region phenotype ( J:291983 )

N • normal body size and weight

muscle

muscle phenotype ( J:291983 )

N • normal tibialis anterior (TA) and gastrocnemius (GAS) muscle weight at age 8 weeks

increased variability of skeletal muscle fiber size ( J:291983 )

• more small diameter muscle fibers in tibialis anterior (TA) muscle weight at age 8 weeks

skeletal muscle fibrosis ( J:291983 )

• increased diaphragm muscle fibrosis at age 6-8 months

impaired skeletal muscle regeneration ( J:291983 )

• increased size of unrepaired areas in tibialis anterior (TA) muscle weight at age 8 weeks

• increased number of embryonic myosin heavy chain expressing myofibers in tibialis anterior (TA) muscle weight at age 8 weeks

• increased CD68+ macrophage infiltration in tibialis anterior (TA) muscle weight at age 8 weeks