Analysis Tools
mortality/aging
 |
• mice start dying from 26 weeks of age and 72.2% die by 30 weeks of age
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growth/size/body
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• body weight increases normally until 14 weeks of age but does not increase as much as in wild-type mice after 16 weeks of age
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renal/urinary system
albuminuria
(
J:283613
)
|
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• urinary albumin levels tend to be increased at 6 weeks of age and increase with age, remaining high after 22 weeks of age
• urinary albumin corrected by creatinine is increased with aging
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• 22-week old mice show thickened Bowmans capsule
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• 6-week old mice show occasional foot process effacement
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• 6-week old mice show focal irregularity of glomerular basement membrane
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• 22-week old mice show thickening with matrix lamination in glomerular basement membrane
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• few glomeruli exhibit collapsed glomerular tuft accompanied by parietal cell hyperplasia mimicking crescent formation in 6-week old mice
• tubulointerstitial changes are limited to the peri-glomerular area of involved glomeruli
• marked glomerular changes are seen at 22 weeks, including glomerular tuft collapse with thickened Bowmans capsule
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• 22-week old mice exhibit increased mesangial matrices
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• tubulointerstitial changes are associated with accumulated glomerulosclerosis
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• 6-week old mice exhibit tubulointerstitial fibrosis
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homeostasis/metabolism
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• increases with aging
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• increases with aging
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albuminuria
(
J:283613
)
|
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• urinary albumin levels tend to be increased at 6 weeks of age and increase with age, remaining high after 22 weeks of age
• urinary albumin corrected by creatinine is increased with aging
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| X-linked Alport syndrome | DOID:0110034 |
OMIM:301050 |
J:283613 | |
