Phenotypes Associated with This Genotype

Genotype
MGI:6479897

• Allelic Composition: Tcf4^{tm1a(EUCOMM)Wtsi}/Tcf4⁺
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal corpus callosum morphology ( J:265025 )

• mice show agenesis of the splenium of the corpus callosum

abnormal dentate gyrus morphology ( J:265025 )

• dentate gyrus volume is decreased

decreased hippocampus volume ( J:265025 )

• reduction in hippocampal volume

thin cerebral cortex ( J:265025 )

• cortical thickness is reduced in all analyzed areas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Pitt-Hopkins syndrome		DOID:0060488	OMIM:610954	J:265025