Phenotypes Associated with This Genotype

Genotype
MGI:6488227

• Allelic Composition: Btbd9^{tm1c(EUCOMM)Wtsi}/Btbd9^{tm1c(EUCOMM)Wtsi}; Tg(Pcp2-cre)2Mpin/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased locomotor activity ( J:298663 )

• mice exhibit an increase in voluntary activity level in the wheel-running test during the light phase, but no change during the dark phase; activity is especially high at 9 am and especially low during the 1st half of the active phase

• mice exhibit an increase in activity level during the rest (light) phase and during the active (dark) phase in the continuous open field

• however, mice show no difference in the latency to withdraw from the heat stimuli in the tail-flick test

abnormal sleep behavior ( J:298663 )

• analysis of sleep-like behaviors indicates an increase in probability of waking in the rest phase, especially at 7 am, 8 am and the 2nd half of the rest phase, but not in the active phase

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
restless legs syndrome		DOID:0050425	OMIM:PS102300	J:298663