Analysis Tools
behavior/neurological
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• mice exhibit a 219% increase of slips in the beam walking test
• however, mice do not show a deficit in the rotarod test
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• in the continuous open field test, mice show an increase in activity level during the light phase but not dark phase indicating a rest-phase specific motor restlessness
• however, mice exhibit a similar level of total distance traveled in a 30 min open field test as controls and similar wheel running activity during both the light and dark phase as in controls
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• sleep analysis indicates an increased probability of waking in the light phase but not dark phase
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• mice exhibit lower sensitivity to the heat stimuli than controls in the tail-flick test, indicating decreased thermal sensory perception
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nervous system
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• mice exhibit thinner cortical layers in the posterior primary motor cortex
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• mice exhibit thinner cortical layers in both the anterior and posterior part of the primary somatosensory cortex representing the hindlimb
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| restless legs syndrome | DOID:0050425 |
OMIM:PS102300 |
J:282582 | |
