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Phenotypes Associated with This Genotype
Genotype
MGI:6490510
Allelic
Composition
Ppp3r1tm1.1Jhon/Ppp3r1tm1.1Jhon
Genetic
Background
involves: C57BL/6 * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp3r1tm1.1Jhon mutation (0 available); any Ppp3r1 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice begin to die at 17 months of age, with a survival rate of about 70% at this time

cardiovascular system
• decrease in average cross-sectional area of left ventricle myocytes
• shorter maximum diameter of cardiomyocytes
• the left ventricle chamber is large
• the right ventricle chamber is large
• the left ventricle and right ventricle free walls are thinner
• mice show an increase in fibrosis in hearts, with hearts showing higher levels of type I and type II collagens
• heart weight to body weight ratio is increased and heart mass is increased in 18-month, but not 12-month, old mice
• mice exhibit decreased fractional shortening and decreased left ventricle ejection fraction at 18 months of age
• left ventricular end-diastolic diameter is increased at 18, but not 12, months of age
• mice exhibit an increase in expression of heart failure gene markers at 18 months of age

muscle
• decrease in average cross-sectional area of left ventricle myocytes
• shorter maximum diameter of cardiomyocytes
• heart weight to body weight ratio is increased and heart mass is increased in 18-month, but not 12-month, old mice
• mice exhibit decreased fractional shortening and decreased left ventricle ejection fraction at 18 months of age
• higher rates of apoptotic cardiomyocyte death

cellular
• mice show an increase in fibrosis in hearts, with hearts showing higher levels of type I and type II collagens
• higher rates of apoptotic cardiomyocyte death

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
dilated cardiomyopathy DOID:12930 OMIM:PS115200
J:298603


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory