mortality/aging
• mice begin to die at 17 months of age, with a survival rate of about 70% at this time
|
cardiovascular system
• decrease in average cross-sectional area of left ventricle myocytes
• shorter maximum diameter of cardiomyocytes
|
• the left ventricle chamber is large
|
• the right ventricle chamber is large
|
• the left ventricle and right ventricle free walls are thinner
|
• mice show an increase in fibrosis in hearts, with hearts showing higher levels of type I and type II collagens
|
• heart weight to body weight ratio is increased and heart mass is increased in 18-month, but not 12-month, old mice
|
• mice exhibit decreased fractional shortening and decreased left ventricle ejection fraction at 18 months of age
|
• left ventricular end-diastolic diameter is increased at 18, but not 12, months of age
|
• mice exhibit an increase in expression of heart failure gene markers at 18 months of age
|
muscle
• decrease in average cross-sectional area of left ventricle myocytes
• shorter maximum diameter of cardiomyocytes
|
• heart weight to body weight ratio is increased and heart mass is increased in 18-month, but not 12-month, old mice
|
• mice exhibit decreased fractional shortening and decreased left ventricle ejection fraction at 18 months of age
|
• higher rates of apoptotic cardiomyocyte death
|
cellular
• mice show an increase in fibrosis in hearts, with hearts showing higher levels of type I and type II collagens
|
• higher rates of apoptotic cardiomyocyte death
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
dilated cardiomyopathy | DOID:12930 |
OMIM:PS115200 |
J:298603 |