Phenotypes Associated with This Genotype

Genotype
MGI:6492211

• Allelic Composition: Lrrc7^{Tg(Myl2-TSPYL)1Sich}/Lrrc7^{Tg(Myl2-TSPYL)1Sich}
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:293568 )

• mice die of dehydration if not fed with wet chow from P17 to P32

growth/size/body

decreased body size ( J:293568 )

• mice are smaller in size around weaning but catch up in size at the 5th week

behavior/neurological

abnormal spatial working memory ( J:293568 )

♂ • mice show reduced alternation in arm entry in the Y-maze, indicating impaired spatial working memory

increased aggression towards mice ( J:293568 )

♂ • mice follow littermates excessively, resulting in fighting and injuries, indicating inappropriate juvenile aggressive behavior

♂ • however, no aggressive behavior in the one-chamber test is seen

increased thigmotaxis ( J:293568 )

♂ • mice show elevated anxiety, with fewer entries to the center zone and less time spent in the center zone in the open field and spending more time in closed arms are fewer entries in open arms in the elevated-plus maze

♂ • CDPPB injection ameliorates the anxiety-like behavior

♂ • however, mice show a mild defect in sucrose consumption only on the first day of habituation but not the remaining 5 days, suggesting no anhedonia and show normal behavior in the forced swim test indicating no evidence of depression and exhibit normal locomotion in the open field test at 8-10 weeks of age

impaired coordination ( J:293568 )

• more mice drop off the hanging wire before the cut-off time than wild-type mice

• however, 8-10 week old mice exhibit normal motor strength in the hanging wire test

abnormal social investigation ( J:293568 )

♂ • mice spend more time in sniffing the stranger mouse both in the one-chamber test and the three-chamber test

♂ • 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide (CDPPB) injection reduces the hyper-sociability

homeostasis/metabolism

dehydration ( J:293568 )

• mice die of dehydration if not fed with wet chow from P17 to P32

nervous system

abnormal neurite morphology ( J:293568 )

♂ • pyramidal neuron neurite morphogenesis is impaired

abnormal hippocampal pyramidal neuron dendrite morphology ( J:293568 )

♂ • pyramidal neurons from the CA1 region of the hippocampus exhibit elongated dendritic spines

♂ • pyramidal neurons show reduced dendritic complexity, with reduced length and branching starting at the third order for basal dendrites and at the seventh or eighth order for apical dendrites

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
developmental disorder of mental health		DOID:0060037		J:293568