Phenotypes Associated with This Genotype

Genotype
MGI:6492795

hm1

• Allelic Composition: Ddx46^em1(IMPC)Tcp/Ddx46^em1(IMPC)Tcp
• Genetic Background: C57BL/6N-Ddx46^em1(IMPC)Tcp/Cmmr

Data Sources

IMPC Data for Ddx46

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Ddx46^em1(IMPC)Tcp/Ddx46^em1(IMPC)Tcp mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts hatch from the zona pellucida but form irregular outgrowths.

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - TCP

preweaning lethality, complete penetrance ( J:211773 )

IMPC - TCP

embryonic lethality between implantation and somite formation, complete penetrance ( J:279207 )

• blastocysts are present at E3.5 (14% versus expected 25%, n=29); no homozygous embryos are recovered at E7.5

• however, excess resorption sites suggest that embryos elicit a decidual response in vivo

reproductive system

abnormal embryo implantation ( J:279207 )

• in vitro, blastocysts hatch from the zona pellucida but form irregular outgrowths after 3 days in culture