Phenotypes Associated with This Genotype

Genotype
MGI:6501768

• Allelic Composition: Cpa1^tm1.1Satom/Cpa1^tm1.1Satom
• Genetic Background: involves: C57BL/6NCrl * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal pancreatic acinar cell morphology ( J:300042 )

• vacuolization and concentric arrangement of endoplasmic reticulum stacks in acinar cells

decreased pancreatic acinar cell number ( J:300042 )

• some cells are lost by 12 months of age

small pancreas ( J:300042 )

• starting at 3 months

decreased pancreas weight ( J:300042 )

• at 6 months of age

pancreas atrophy ( J:300042 )

• at 6 months of age

pancreatic acinar-to-ductal metaplasia ( J:300042 )

abnormal pancreas physiology ( J:300042 )

• elevated trypsin activity in the pancreata at 1, 3, and 6 months

pancreas inflammation ( J:300042 )

• progressive and chronic

homeostasis/metabolism

increased circulating hydroxyproline level ( J:300042 )

increased circulating amylase level ( J:300042 )

• at 1 months but not at 3 and 6 months

immune system

pancreas inflammation ( J:300042 )

• progressive and chronic

digestive/alimentary system

abnormal pancreatic acinar cell morphology ( J:300042 )

• vacuolization and concentric arrangement of endoplasmic reticulum stacks in acinar cells

decreased pancreatic acinar cell number ( J:300042 )

• some cells are lost by 12 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatitis		DOID:4989	OMIM:167800	J:300042