Phenotypes Associated with This Genotype

Genotype
MGI:6501995

• Allelic Composition: Ifnar1^tm1Agt/Ifnar1^tm1Agt; Tg(CD46)373Zbz/Tg(CD46)373Zbz
• Genetic Background: involves: 129S2/SvPas * C3H/He * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to Paramyxoviridae infection induced morbidity/mortality ( J:160878 )

• mice inoculated intracerebrally with the attenuated Edmonston measles virus (MV-Edm) show increased lethality after two days post infection

• 50% of mice inoculated with the rat brain-adapted neurotrophic measles virus strain CAM/RBH succumb 5-11 days post infection

immune system

brain inflammation ( J:160878 )

• mice infected intracerebrally with MV-Edm show encephalitis

meningitis ( J:160878 )

• mice infected intracerebrally with MV-Edm exhibit meningitis with inflammatory infiltrates of leukocytes and extensive vacuolization and necrosis of nearby brain parenchyma

lung inflammation ( J:160878 )

• mice inoculated intranasally with MV-Edm show acute lung inflammation

increased susceptibility to Paramyxoviridae infection ( J:160878 )

• mice inoculated intranasally with the attenuated Edmonston measles virus (MV-Edm) show larger purple lesions in the lungs than seen in Ifnar1^tm1Agt homozygotes

• mice inoculated intranasally with MV-Edm show acute lung inflammation, extensive hyperemia, and diffuse hemorrhage in large areas of the lungs and show peak virus levels in the lungs at day 6 post infection which spreads to liver, spleen, kidney, and peripheral blood mononuclear cells

• susceptibility to MV-Edm infection is more pronounced if less virus is inoculated

• mice inoculated intracerebrally with MV-Edm show increased lethality after two days post infection and show clinical signs of neural disease, including initial hyperactivity followed by awkward gait, lethargy, lack of mobility, and death

increased susceptibility to Paramyxoviridae infection induced morbidity/mortality ( J:160878 )

• mice inoculated intracerebrally with the attenuated Edmonston measles virus (MV-Edm) show increased lethality after two days post infection

• 50% of mice inoculated with the rat brain-adapted neurotrophic measles virus strain CAM/RBH succumb 5-11 days post infection

respiratory system

lung hemorrhage ( J:160878 )

• mice inoculated intranasally with MV-Edm show diffuse hemorrhage in large areas of the lungs

pulmonary hyperemia ( J:160878 )

• mice inoculated intranasally with MV-Edm show extensive hyperemia

lung inflammation ( J:160878 )

• mice inoculated intranasally with MV-Edm show acute lung inflammation

nervous system

brain inflammation ( J:160878 )

• mice infected intracerebrally with MV-Edm show encephalitis

meningitis ( J:160878 )

• mice infected intracerebrally with MV-Edm exhibit meningitis with inflammatory infiltrates of leukocytes and extensive vacuolization and necrosis of nearby brain parenchyma

astrocytosis ( J:160878 )

• mice infected intracerebrally with MV-Edm show numerous reactive astrocytes in many brain areas

abnormal neuron physiology ( J:160878 )

• mice infected intracerebrally with MV-Edm exhibit necrosis of neurons in the cerebral cortex, corpus callosum, and hypothalamus

behavior/neurological

lethargy ( J:160878 )

• mice inoculated intracerebrally with MV-Edm show initial hyperactivity that is followed by awkward gait and lethargy

abnormal gait ( J:160878 )

• mice inoculated intracerebrally with MV-Edm show initial hyperactivity followed by awkward gait and lack of mobility

induced hyperactivity ( J:160878 )

• mice inoculated intracerebrally with MV-Edm show initial hyperactivity following infection

cardiovascular system

lung hemorrhage ( J:160878 )

• mice inoculated intranasally with MV-Edm show diffuse hemorrhage in large areas of the lungs

pulmonary hyperemia ( J:160878 )

• mice inoculated intranasally with MV-Edm show extensive hyperemia

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
measles		DOID:8622		J:160878