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Phenotypes Associated with This Genotype
Genotype
MGI:6505558
Allelic
Composition		 Apctm2Rak/Apc+
Krastm4Tyj/Kras+
Tg(Fabp1-cre)1Jig/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm2Rak mutation (1 available); any Apc mutation (158 available)
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Tg(Fabp1-cre)1Jig mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased colon adenoma incidence ( J:276349 )
• mice develop colonic tumors, characterized as adenomas with low-grade dysplasia

mortality/aging
premature death ( J:276349 )
• mice show 100% lethality before 150 days of age

digestive/alimentary system
increased colon adenoma incidence ( J:276349 )
• mice develop colonic tumors, characterized as adenomas with low-grade dysplasia

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
colorectal cancer DOID:9256 OMIM:114500
 J:276349

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory