homeostasis/metabolism
• plasma levels of total cholesterol are increased at 10 and 28 weeks of age, indicating hypercholesterolemia that worsens with age
• mice treated with evolocumab, a monoclonal antibody that inhibits human PCSK9, show reduced plasma cholesterol levels
|
• plasma levels of LDL cholesterol are increased at 10 and 28 weeks of age
|
growth/size/body
N |
• body weight is normal at 28 weeks of age
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
familial hypercholesterolemia | DOID:13810 |
OMIM:143890 |
J:280156 |