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Phenotypes Associated with This Genotype
Genotype
MGI:6506468
Allelic
Composition
Gt(ROSA)26Sortm1.1(Alb-PCSK9)Mby/Gt(ROSA)26Sor+
Genetic
Background
involves: C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1.1(Alb-PCSK9)Mby mutation (0 available); any Gt(ROSA)26Sor mutation (992 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• plasma levels of total cholesterol are increased at 10 and 28 weeks of age, indicating hypercholesterolemia that worsens with age
• mice treated with evolocumab, a monoclonal antibody that inhibits human PCSK9, show reduced plasma cholesterol levels
• plasma levels of LDL cholesterol are increased at 10 and 28 weeks of age

growth/size/body
N
• body weight is normal at 28 weeks of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
familial hypercholesterolemia DOID:13810 OMIM:143890
J:280156


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory