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Phenotypes Associated with This Genotype
Genotype
MGI:6506863
cn20
Allelic
Composition		 Jamltm1Fnyi/Jaml+
Leprdb/Leprdb
Tg(NPHS2-cre)295Lbh/0
Genetic
Background		 B6.Cg-Leprdb Jamltm1Fnyi Tg(NPHS2-cre)295Lbh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jamltm1Fnyi mutation (0 available); any Jaml mutation (23 available)
Leprdb mutation (17 available); any Lepr mutation (125 available)
Tg(NPHS2-cre)295Lbh mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
increased urine protein level ( J:300243 )
• intermediate but not as severe as in mice with wild-type Jaml
abnormal podocyte morphology ( J:300243 )
• podocyte injury that is as severe as in mice with wild-type Jaml
expanded mesangial matrix ( J:300243 )
• not as severe as in mice with wild-type Jaml

homeostasis/metabolism
increased urine protein level ( J:300243 )
• intermediate but not as severe as in mice with wild-type Jaml

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory