Phenotypes for Jaml Lepr Tg(NPHS2-cre)295Lbh MGI:6506864 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Jaml^tm1Fnyi/Jaml^tm1Fnyi Lepr^db/Lepr^db Tg(NPHS2-cre)295Lbh/0
Genetic Background	B6.Cg-Lepr^db Jaml^tm1Fnyi Tg(NPHS2-cre)295Lbh

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jaml^tm1Fnyi mutation (0 available); any Jaml mutation (23 available)
Lepr^db mutation (17 available); any Lepr mutation (125 available)
Tg(NPHS2-cre)295Lbh mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

increased urine protein level ( J:300243 )

• not as severe as in mice with wild-type Jaml

abnormal podocyte morphology ( J:300243 )

• podocyte injury that is as severe as in mice with wild-type Jaml

expanded mesangial matrix ( J:300243 )

• not as severe as in mice with wild-type Jaml

renal glomerulus lipidosis ( J:300243 )

• not as severe as in mice with wild-type Jaml

homeostasis/metabolism

increased urine protein level ( J:300243 )

• not as severe as in mice with wild-type Jaml

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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