neoplasm
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• mice show an earlier onset of hematopoietic neoplasms that spontaneously occur in wild-type mice
• tumors are localized to the liver, spleen, and/or lymph nodes
• tumors express T-cell, B-cell, or myeloid/erythroid cell surface makers or show aberrant expression of markers from multiple hematopoietic lineages
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growth/size/body
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• females show reduced body weight by 3 weeks of age
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