Phenotypes Associated with This Genotype

Genotype
MGI:6507387

hm2

• Allelic Composition: Ifi44^{tm1b(KOMP)Wtsi}/Ifi44^{tm1b(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0112_5_H05

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased CD8-positive, alpha-beta T cell number ( J:297991 )

• mice infected intranasally with 1 x 10⁵ PFU of respiratory syncytial virus (RSV) A2 exhibit a higher percentage of live CD8+ cells in the lungs at day 7 post-infection relative to RSV-infected wild-type controls

decreased CXCL10 secretion ( J:297991 )

• mice infected intranasally with 1 x 10⁵ PFU of respiratory syncytial virus (RSV) A2 show a modest but significant reduction in lung CXCL10 levels at day 4 but not at day 7 post-infection relative to RSV-infected wild-type controls

decreased interleukin-1 beta secretion ( J:297991 )

• mice infected intranasally with 1 x 10⁵ PFU of respiratory syncytial virus (RSV) A2 show a modest but significant reduction in lung interleukin-1 beta levels at day 4 post-infection relative to RSV-infected wild-type controls

increased susceptibility to Riboviria infection ( J:297991 )

• mice infected intranasally with 1 x 10⁵ PFU of respiratory syncytial virus (RSV) A2 exhibit greater weight loss from 5 to 7 days post-infection (dpi), higher levels of viral RNA in lung tissue at 4 dpi but not at 7 dpi, and a higher percentage of live CD8+ cells in the lungs at 7 dpi relative to RSV-infected wild-type controls

• however, no difference is observed in total cell numbers isolated from the bronchoalveolar lavage fluid or from whole lung tissue

hematopoietic system

increased CD8-positive, alpha-beta T cell number ( J:297991 )

• mice infected intranasally with 1 x 10⁵ PFU of respiratory syncytial virus (RSV) A2 exhibit a higher percentage of live CD8+ cells in the lungs at day 7 post-infection relative to RSV-infected wild-type controls