Phenotypes Associated with This Genotype

Genotype
MGI:6507858

hm1

• Allelic Composition: Styk1^tm1Twa/Styk1^tm1Twa
• Genetic Background: B6J.B6N-Styk1^tm1Twa

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:277150 )

N • no differences in NK cell development or in vitro NK-cell functions are observed in mutant mice relative to wild-type controls

N • when challenged with mouse cytomegalovirus (MCMV) Smith strain, mice survive the infection and recover in terms of weight, with no differences in serum IFN-gamma levels at day 2 post-infection or in frequency of Ly49H positive NK cells in spleen at day 7 post-infection relative to MCMV-infected wild-type controls