Phenotypes Associated with This Genotype

Genotype
MGI:6507888

• Allelic Composition: Ctnnb1^tm1Mmt/Ctnnb1⁺; Igs2^{tm1(CAG-Met)Zsu}/Igs2⁺; Tg(Pbsn-cre)4Prb/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased prostate gland adenocarcinoma incidence ( J:284956 )

♂ • mice develop aggressive adenocarcinomas that occur with much higher frequency than in single Ctnnb1^tm1Mmt conditional mutants, developing prostatic invasive adenocarcinomas as early as 7 months of age

♂ • 4 of 4 mice show intracystic adenocarcinoma at 6-9 months of age, with 1 of 4 mice showing invasive adenocarcinoma

♂ • 13 of 13 mice show intracystic adenocarcinoma at 9 months or older, with 5 of 13 showing invasive adenocarcinoma

increased prostate intraepithelial neoplasia incidence ( J:284956 )

♂ • mice develop PIN lesions starting at 4-6 weeks of age, with 5 of 5 mice showing high grade PIN before 6 months of age

♂ • mice develop more severe PIN lesions and faster disease progression than single Ctnnb1^tm1Mmt conditional mutants

♂ • lesions in the anterior, dorsal, and lateral prostate lobes are more severe than in the ventral prostate

♂ • typical cribriform and papilliferous structures completely fill the lumen of prostatic glands

neoplasm

increased prostate gland adenocarcinoma incidence ( J:284956 )

♂ • mice develop aggressive adenocarcinomas that occur with much higher frequency than in single Ctnnb1^tm1Mmt conditional mutants, developing prostatic invasive adenocarcinomas as early as 7 months of age

♂ • 4 of 4 mice show intracystic adenocarcinoma at 6-9 months of age, with 1 of 4 mice showing invasive adenocarcinoma

♂ • 13 of 13 mice show intracystic adenocarcinoma at 9 months or older, with 5 of 13 showing invasive adenocarcinoma

increased prostate intraepithelial neoplasia incidence ( J:284956 )

♂ • mice develop PIN lesions starting at 4-6 weeks of age, with 5 of 5 mice showing high grade PIN before 6 months of age

♂ • mice develop more severe PIN lesions and faster disease progression than single Ctnnb1^tm1Mmt conditional mutants

♂ • lesions in the anterior, dorsal, and lateral prostate lobes are more severe than in the ventral prostate

♂ • typical cribriform and papilliferous structures completely fill the lumen of prostatic glands

reproductive system

increased prostate gland adenocarcinoma incidence ( J:284956 )

♂ • mice develop aggressive adenocarcinomas that occur with much higher frequency than in single Ctnnb1^tm1Mmt conditional mutants, developing prostatic invasive adenocarcinomas as early as 7 months of age

♂ • 4 of 4 mice show intracystic adenocarcinoma at 6-9 months of age, with 1 of 4 mice showing invasive adenocarcinoma

♂ • 13 of 13 mice show intracystic adenocarcinoma at 9 months or older, with 5 of 13 showing invasive adenocarcinoma

increased prostate intraepithelial neoplasia incidence ( J:284956 )

♂ • mice develop PIN lesions starting at 4-6 weeks of age, with 5 of 5 mice showing high grade PIN before 6 months of age

♂ • mice develop more severe PIN lesions and faster disease progression than single Ctnnb1^tm1Mmt conditional mutants

♂ • lesions in the anterior, dorsal, and lateral prostate lobes are more severe than in the ventral prostate

♂ • typical cribriform and papilliferous structures completely fill the lumen of prostatic glands

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:284956