Phenotypes Associated with This Genotype

Genotype
MGI:6508539

• Allelic Composition: Pank4^em1Nju/Pank4^em1Nju
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

increased lens epithelium apoptosis ( J:301838 )

• lens epithelial cells exhibit increased apoptosis

abnormal lens morphology ( J:301838 )

• lenses show crystallin protein aggregation

abnormal lens epithelium morphology ( J:301838 )

• lens epithelial cells exhibit a squamous epithelium style rather than the typical simple cuboidal epithelium style

• decrease in thickness of the lens epithelium

abnormal lens fiber morphology ( J:301838 )

• interior fiber cells in the center of the lens are lined unregulary and fiber cell debris accumulates in some specific regions of the lens

• size of fiber cells vary and a difference in area of lens fiber cells is seen

cataract ( J:301838 )

• mice develop cataract with age, with highest 50% incidence at 15 months of age

• cataract plaque is located mainly in the anterior lens

cellular

increased lens epithelium apoptosis ( J:301838 )

• lens epithelial cells exhibit increased apoptosis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract		DOID:83	OMIM:601371 OMIM:PS116200	J:301838