Analysis Tools
craniofacial
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• buccal mucosa shows thickened epithelium, immature suprabasal cells, loss of keratohyalin granules, and disorganized keratin layer
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• tongue appears white and wrinkled, especially on the ventral surface, at 3 weeks of age
• epithelial folds are most prominent in the ventral side, especially close to the root
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• epithelium is thickened and folded, the stratum corneum layer is thickened, the basal and suprabasal layers of the tongue show increased nuclear atypia and vacuolization, and the outermost keratin layer is disorganized and appears foamy
• tongue epithelia shows disrupted layer structure and massive cytoplasmic vacuolization, increased intercellular gaps, broken desmosomes and the intermediate filaments running from the desmosomes to the cytoplasm are missing or reduced, loss of keratohyalin granules and accumulation of big lipid droplets in the granular cells
• tongue epithelium shows an expansion of proliferating cells to the upper layers of the epithelium
• marker analysis indicates epithelial proliferation and differentiation defects in the tongue at P20
• however, no abnormalities in gross morphology, structural architecture, or cell proliferation are seen in tongues at P0
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digestive/alimentary system
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• buccal mucosa shows thickened epithelium, immature suprabasal cells, loss of keratohyalin granules, and disorganized keratin layer
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• tongue appears white and wrinkled, especially on the ventral surface, at 3 weeks of age
• epithelial folds are most prominent in the ventral side, especially close to the root
|
|
• epithelium is thickened and folded, the stratum corneum layer is thickened, the basal and suprabasal layers of the tongue show increased nuclear atypia and vacuolization, and the outermost keratin layer is disorganized and appears foamy
• tongue epithelia shows disrupted layer structure and massive cytoplasmic vacuolization, increased intercellular gaps, broken desmosomes and the intermediate filaments running from the desmosomes to the cytoplasm are missing or reduced, loss of keratohyalin granules and accumulation of big lipid droplets in the granular cells
• tongue epithelium shows an expansion of proliferating cells to the upper layers of the epithelium
• marker analysis indicates epithelial proliferation and differentiation defects in the tongue at P20
• however, no abnormalities in gross morphology, structural architecture, or cell proliferation are seen in tongues at P0
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• esophagus shows thickened epithelium, immature suprabasal cells, loss of keratohyalin granules, and disorganized keratin layer
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growth/size/body
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• buccal mucosa shows thickened epithelium, immature suprabasal cells, loss of keratohyalin granules, and disorganized keratin layer
|
|
• tongue appears white and wrinkled, especially on the ventral surface, at 3 weeks of age
• epithelial folds are most prominent in the ventral side, especially close to the root
|
|
• epithelium is thickened and folded, the stratum corneum layer is thickened, the basal and suprabasal layers of the tongue show increased nuclear atypia and vacuolization, and the outermost keratin layer is disorganized and appears foamy
• tongue epithelia shows disrupted layer structure and massive cytoplasmic vacuolization, increased intercellular gaps, broken desmosomes and the intermediate filaments running from the desmosomes to the cytoplasm are missing or reduced, loss of keratohyalin granules and accumulation of big lipid droplets in the granular cells
• tongue epithelium shows an expansion of proliferating cells to the upper layers of the epithelium
• marker analysis indicates epithelial proliferation and differentiation defects in the tongue at P20
• however, no abnormalities in gross morphology, structural architecture, or cell proliferation are seen in tongues at P0
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| white sponge nevus | DOID:0050448 |
OMIM:PS193900 |
J:297664 | |
