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Phenotypes Associated with This Genotype
Genotype
MGI:6510523
Allelic
Composition
Ndor1Tg(UBC-cre/ERT2)1Ejb/Ndor1+
Rpl11tm1.1Srn/Rpl11+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6NCrl * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndor1Tg(UBC-cre/ERT2)1Ejb mutation (6 available); any Ndor1 mutation (32 available)
Rpl11tm1.1Srn mutation (1 available); any Rpl11 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• tamoxifen-treated mice show defective erythropoiesis, with bone marrow showing an increase in the percentage of primitive progenitors and proerythroblasts (RI cells) and a decrease in the more matured stages (RIII, RIV, and RV cells)
• fetal livers from tamoxifen-treated pregnant mothers show an increase in the percentage of primitive progenitors and proerythroblasts (RI cells) and a decrease in the more matured stages (RIII, RIV, and RV cells)
• bone marrow of transplanted SCID mice show an increase in the percentage of primitive progenitors and proerythroblasts (RI cells) and a decrease in the more matured stages (RIII, RIV, and RV)
• fetal liver erythroid progenitors from tamoxifen-treated pregnant mothers show lower proliferation (increase in cells in G1 and a tendency of decrease in cells in S phase)
• tamoxifen-treated mice develop anemia
• mice irradiated with a single dose of gamma-radiation and treated with tamoxifen 1 week later develop anemia
• bone marrow of tamoxifen-treated mice shows an increase in the percentage of primitive progenitors and proerythroblasts (RI cells)
• bone marrow of transplanted SCID mice show an increase in the percentage of primitive progenitors and proerythroblasts (RI cells)
• bone marrow shows a decrease in the number of erythroblasts in tamoxifen-treated mice
• mutant bone marrow transplanted SCID mice show a severe decrease in erythroblasts
• however, the bone marrow is histologically normocellular and has normal ratios of hematopoietic stem cells and progenitor cells
• mice fed a tamoxifen diet starting at 1.5-2 months of age exhibit lower red blood cell levels which becomes more pronounced with age
• mutant bone marrow transplanted SCID mice show reduced red blood cell levels over time
• mutant bone marrow transplanted SCID mice show decreased hemoglobin levels over time
• tamoxifen-treated mice exhibit macrocytosis which becomes more pronounced with age

homeostasis/metabolism
• gamma-irradiated mice treated with tamoxifen die earlier than controls

mortality/aging
• gamma-irradiated mice treated with tamoxifen die earlier than controls

neoplasm
• gamma-irradiated mice treated with tamoxifen develop lymphomas, particularly in the thymus

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Diamond-Blackfan anemia 7 DOID:0111878 OMIM:612562
J:292575


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory