Phenotypes for Prickle3 MGI:6514802 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Prickle3^em1Mxg/Y
Genetic Background	C57BL/6JSlacc-Prickle3^em1Mxg

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prickle3^em1Mxg mutation (0 available); any Prickle3 mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal retina blood vessel morphology ( J:300151 )

• tortuous and dilated with more branches in vessels

increased retina vascular tortuosity ( J:300151 )

retina ganglion cell degeneration ( J:300151 )

abnormal cone electrophysiology ( J:300151 )

• reduced b-wave

abnormal rod electrophysiology ( J:300151 )

• reduced b-wave

nervous system

abnormal retina ganglion cell dendrite morphology ( J:300151 )

retina ganglion cell degeneration ( J:300151 )

cardiovascular system

abnormal retina blood vessel morphology ( J:300151 )

• tortuous and dilated with more branches in vessels

increased retina vascular tortuosity ( J:300151 )

cellular

abnormal mitochondrial morphology ( J:300151 )

• with vacuolated, fragmented mitochondria and the loss of cristae in the retina

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Leber plus disease		DOID:0111754		J:300151

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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