Phenotypes Associated with This Genotype

Genotype
MGI:6515750

• Allelic Composition: Vcpip1^em1Zlou/Vcpip1^em1Zlou
• Genetic Background: C57BL/6NHsd-Vcpip1^em1Zlou

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

abnormal inguinal fat pad morphology ( J:297179 )

• significant senescence of inguinal adipose tissue (IAT)

cellular

abnormal chromosome morphology ( J:297179 )

• large increase in number of abnormal chromosomes in mouse embryo fibroblasts (MEFs)

• significant increase in number of micronuclei in normochromic erythrocytes (NCEs)

• increased accumulation of camptothecin (CPT)-induced topoisomerase 1 cleavage complex (Top1cc) foci in liver at age 4 months and in MEFs

increased cellular sensitivity to DNA damaging agents ( J:297179 )

• hypersensitive to DNA-protein crosslink (DPC)-inducing agents formaldehyde (FA), camptothecin (CPT) and cisplatin in mouse embryo fibroblasts (MEFs)

abnormal DNA repair ( J:297179 )

• failure to repair DNA-protein crosslinks (DPCs) in mouse embryo fibroblasts (MEFs)

• increased accumulation of camptothecin (CPT)-induced topoisomerase 1 cleavage complex (Top1cc) foci in liver at age 4 months and in MEFs

chromosomal instability ( J:297179 )

• large increase in number of abnormal chromosomes in mouse embryo fibroblasts (MEFs)

• failure to repair DNA-protein crosslinks (DPCs) in mouse embryo fibroblasts (MEFs)

• significant increase in number of micronuclei in normochromic erythrocytes (NCEs)

• increased accumulation of camptothecin (CPT)-induced topoisomerase 1 cleavage complex (Top1cc) foci in liver at age 4 months and in MEFs

growth/size/body

decreased body weight ( J:297179 )

homeostasis/metabolism

abnormal DNA repair ( J:297179 )

• failure to repair DNA-protein crosslinks (DPCs) in mouse embryo fibroblasts (MEFs)

• increased accumulation of camptothecin (CPT)-induced topoisomerase 1 cleavage complex (Top1cc) foci in liver at age 4 months and in MEFs

mortality/aging

premature death ( J:297179 )

• reduced median lifespan

skeleton

kyphosis ( J:297179 )

• at age 10 months

lordosis ( J:297179 )

• at age 10 months

vision/eye

cataract ( J:297179 )

• increased incidence of cataracts at age 10 months

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
progeria		DOID:3911	OMIM:176670	J:297179