Phenotypes Associated with This Genotype

Genotype
MGI:6515758

cn3

• Allelic Composition: Polr2m^tm1.1Rgr/Polr2m^tm1.1Rgr; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

liver/biliary system phenotype ( J:291184 )

N • liver weights are similar to controls

increased hepatocyte karyomegaly ( J:291184 )

• large cells with enlarged nuclei are seen

abnormal hepatocyte physiology ( J:291184 )

• expression analysis indicates more cells have re-entered the cell cycle but that the cell cycle appears to arrest

homeostasis/metabolism

decreased circulating triglyceride level ( J:291184 )

increased circulating alkaline phosphatase level ( J:291184 )

cellular

increased hepatocyte karyomegaly ( J:291184 )

• large cells with enlarged nuclei are seen