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Phenotypes Associated with This Genotype
Genotype
MGI:6515760
cn2
Allelic
Composition		 Polr2mtm1.1Rgr/Polr2mtm1.1Rgr
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polr2mtm1.1Rgr mutation (0 available); any Polr2m mutation (20 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (244 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
increased hepatocyte apoptosis ( J:291184 )
• dramatically increased by 8 weeks of age
increased hepatocyte proliferation ( J:291184 )
• expression analysis indicates more cells have re-entered the cell cycle and at 8 weeks of age the number of Ki67 positive hepatocytes is further increased
abnormal liver morphology ( J:291184 )
• liver architecture is distorted with the pericentral expression pattern of glutamine synthetase absent
abnormal hepatocyte morphology ( J:291184 )
• increased size with some being extremely enlarged and containing more than 3 nuclei indicating incomplete mitoses

cellular
increased hepatocyte apoptosis ( J:291184 )
• dramatically increased by 8 weeks of age
increased hepatocyte proliferation ( J:291184 )
• expression analysis indicates more cells have re-entered the cell cycle and at 8 weeks of age the number of Ki67 positive hepatocytes is further increased

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory