Analysis Tools
homeostasis/metabolism
albuminuria
(
J:302901
)
|
• albuminuria is seen at 2 weeks of age
• adults exhibit higher urine albumin-creatinine ratios
• however, adults show no evidence of proteinuria or weight loss
|
renal/urinary system
|
• isolated podocytes exhibit decreased attachment in an attachment assay
• preincubation of podocytes with Y26732 corrects the attachment defect
|
|
• isolated podocytes exhibit impaired migration in a wound assay
• preincubation of podocytes with Y26732, a ROCK inhibitor that inhibits RhoA signaling, partially abrogates the migration defect
|
albuminuria
(
J:302901
)
|
• albuminuria is seen at 2 weeks of age
• adults exhibit higher urine albumin-creatinine ratios
• however, adults show no evidence of proteinuria or weight loss
|
|
• mice show foot process effacement at 4 months of age
|
|
• mice exhibit abnormal slit diaphragms at 4 months of age
|
|
• mice exhibit irregular glomerular basement membrane at 4 months of age
|
|
• mice exhibit mesangial expansion at 4 months of age
|
|
• mice show focal segmental glomerulosclerosis of various severity at 4 months of age
• however, tubular atrophy and dilatation or interstitial infiltrates are not seen
|
cellular
|
• isolated podocytes exhibit decreased attachment in an attachment assay
• preincubation of podocytes with Y26732 corrects the attachment defect
|
|
• isolated podocytes exhibit impaired migration in a wound assay
• preincubation of podocytes with Y26732, a ROCK inhibitor that inhibits RhoA signaling, partially abrogates the migration defect
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| focal segmental glomerulosclerosis | DOID:1312 |
OMIM:PS603278 |
J:302901 | |
