Phenotypes Associated with This Genotype

Genotype
MGI:6690322

cn11

• Allelic Composition: Ins2^Akita/Ins2^Akita; Jazf1^{tm1c(EUCOMM)Wtsi}/Jazf1^{tm1c(EUCOMM)Wtsi}; Tg(Ins2-cre)23Herr/0
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N * C57BL/6NSlc * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased pancreatic beta cell apoptosis ( J:303318 )

• at age 8 weeks

decreased pancreatic beta cell proliferation ( J:303318 )

• 70% reduction

endocrine/exocrine glands

increased pancreatic beta cell apoptosis ( J:303318 )

• at age 8 weeks

decreased pancreatic beta cell proliferation ( J:303318 )

• 70% reduction

decreased pancreatic beta cell mass ( J:303318 )

• 50% reduction

growth/size/body

growth/size/body region phenotype ( J:303318 )

N • normal body weight

homeostasis/metabolism

abnormal glucose homeostasis ( J:303318 )

• increased proinsulin levels

increased circulating glucose level ( J:303318 )