Phenotypes for Col1a1 Sst MGI:6693445 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Col1a1^{tm1(tetO-GFP,-RNAi:Eef1a1)Mcg}/Col1a1⁺ Sst^{tm2.1(cre)Zjh}/Sst⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1^{tm1(tetO-GFP,-RNAi:Eef1a1)Mcg} mutation (0 available); any Col1a1 mutation (166 available)
Sst^{tm2.1(cre)Zjh} mutation (4 available); any Sst mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:297390 )

N	• mice virally expressing a cre-dependent tet transactivator exhibit normal behavior in an open field and exploration of an elevated plus maze

impaired cued conditioning behavior ( J:297390 )

• mice virally expressing a cre-dependent tet transactivator exhibit reduced long term memory in a cued threat-conditioning paradigm compared with wild-type

• however, supplementation with doxycycline rescues phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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