Phenotypes Associated with This Genotype

Genotype
MGI:6694853

cn2

• Allelic Composition: Gli1^{tm3(cre/ERT2)Alj}/Gli1⁺; Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺; Tnn^{tm1b(KOMP)Wtsi}/Tnn^{tm1b(KOMP)Wtsi}
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal tooth development ( J:302206 )

• after tamoxifen injection, lineage tracing experiments revealed differentiation and proliferation defects in the incisor stem cell compartment at 3 months of age

• GFP+ Gli1 expressing cells are decreased in number and in area in the incisor pulp, indicating decreased hedgehog signaling

• Ki67 immunostaining showed that the proliferation rate of putative mesenchymal stem cells is reduced

growth/size/body

abnormal tooth development ( J:302206 )

• after tamoxifen injection, lineage tracing experiments revealed differentiation and proliferation defects in the incisor stem cell compartment at 3 months of age

• GFP+ Gli1 expressing cells are decreased in number and in area in the incisor pulp, indicating decreased hedgehog signaling

• Ki67 immunostaining showed that the proliferation rate of putative mesenchymal stem cells is reduced

skeleton

abnormal tooth development ( J:302206 )

• after tamoxifen injection, lineage tracing experiments revealed differentiation and proliferation defects in the incisor stem cell compartment at 3 months of age

• GFP+ Gli1 expressing cells are decreased in number and in area in the incisor pulp, indicating decreased hedgehog signaling

• Ki67 immunostaining showed that the proliferation rate of putative mesenchymal stem cells is reduced