Analysis Tools
behavior/neurological
 N |
• normal behavior and mobility in open field test
• normal behavior in marble burying test
• normal self-grooming behavior
• normal motor coordination and balance
|
|
|
• no increased latency to fall at days 2 and 3 in accelerated rotarod test (wild-type mice increase latency)
|
|
|
• no difference in interaction with novel mouse cage vs familiar mouse cage (wild-type mice spend more time with novel mouse)
• normal behavior in novel mouse cage vs empty cage test: more time spent with mouse
|
nervous system
|
|
• normal cortical thickness
• increased hemisphere length and cortical area at age P20
|
|
|
• at age P20 and in E18.5 embryos
• increased brain-to-body weight ratio
• normal cortical thickness
|
|
|
• increased Tbr1+ neurons in E16.5 embryos and Tbr1+ neurons and Ctip2+ neurons in E18.5 embryos
• increased Cux1+ neurons t age P20
• normal Cux1+ neurons in E18.5 embryos
• normal distribution of Tbr1+, Cux1+ and Ctip2+ neurons in embryos
• normal numbers of Tbr1+, Cux1+ and Ctip2+ neurons in E14.5 embryos
|
|
|
• increased Tbr1+ neurons in E16.5 embryos and Tbr1+ neurons and Ctip2+ neurons in E18.5 embryos
• increased Cux1+ neurons t age P20
• normal Cux1+ neurons in E18.5 embryos
• increased proliferation and decreased cell cycle exit of neuronal precursor cells (NPCs) in E14.5 embryos
|
growth/size/body
|
N |
• normal body size, no gross dysmorphologies
|
|
|
• slightly decreased body weight at age P20
• increased brain-to-body weight ratio
|
mortality/aging
|
N |
• viable
|
reproductive system
|
N |
• fertile
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| syndromic X-linked intellectual disability | DOID:0060309 |
OMIM:PS309510 |
J:287752 | |
