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Phenotypes Associated with This Genotype
Genotype
MGI:6712292
cx4
Allelic
Composition		 Hmox1tm1Poss/Hmox1+
Slc48a1em1Ih/Slc48a1em1Ih
Genetic
Background		 involves: 129 * 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hmox1tm1Poss mutation (1 available); any Hmox1 mutation (35 available)
Slc48a1em1Ih mutation (0 available); any Slc48a1 mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:282829 )
• decreased ratio of Hmox1 heterozygous, Slc48a1 homozygous offspring at birth indicating an almost 40% prenatal lethality

hematopoietic system
impaired hematopoiesis ( J:282829 )
• decrease in the total number of Ter-119+ cells in the bone marrow and spleen
• reduction in total Ter-119+ cells is increased compared to mice wild-type for Slc48a1
increased erythroid progenitor cell number ( J:282829 )
• increase in immature erythroid precursor cells (population II+III) in the spleen
decreased macrophage cell number ( J:282829 )
• decrease in the number of reticuloendothelial macrophages
• reduction in splenic reticuloendothelial macrophages is increased compared to mice wild-type for Slc48a1

immune system
decreased macrophage cell number ( J:282829 )
• decrease in the number of reticuloendothelial macrophages
• reduction in splenic reticuloendothelial macrophages is increased compared to mice wild-type for Slc48a1

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory