Phenotypes Associated with This Genotype

Genotype
MGI:6712682

• Allelic Composition: Apc^Min/Apc⁺
• Genetic Background: C57BL/6J-Apc^Min/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:331404 )

• mice show a median survival time of 24.6 weeks

neoplasm

increased intestinal adenoma incidence ( J:331404 )

• mice exhibit frequent carcinoma-like high-grade adenomas in the small intestine and colon

increased colon adenoma incidence ( J:331404 )

immune system

abnormal interleukin secretion ( J:305794 )

• naive T cells polarized toward the TH22 cell lineage show an increase in IL-22 secretion

digestive/alimentary system

increased intestinal adenoma incidence ( J:331404 )

• mice exhibit frequent carcinoma-like high-grade adenomas in the small intestine and colon

increased colon adenoma incidence ( J:331404 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
colorectal cancer		DOID:9256	OMIM:114500	J:331404