Phenotypes Associated with This Genotype

Genotype
MGI:6712738

cn1

• Allelic Composition: Il22ra1^tm1.1Koll/Il22ra1^tm1.1Koll; Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺
• Genetic Background: involves: BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased erythroid progenitor cell number ( J:305794 )

• mice treated with phenylhydrazine to induce stress erythropoiesis show an increase in RIII and RIV erythroid precursors in the bone marrow compared to controls

increased erythrocyte cell number ( J:305794 )

• mice treated with phenylhydrazine to induce stress erythropoiesis show an increase in peripheral blood red blood cell numbers compared to controls

increased hematocrit ( J:305794 )

• mice treated with phenylhydrazine to induce stress erythropoiesis show an increase in hematocrit compared to controls

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:305794 )

• mice show alleviation of stress-induced anemia, showing increased peripheral blood cell counts, increased hematocrit, and increase in erythroid precursors in the bone marrow following phenylhydrazine-induced stress erythropoiesis